The study investigated the effect of either nocturnal acid suppression by the H2 antagonist nizatidine 300 mg at night or prolonged acid suppression by the proton-pump inhibitor omeprazole 20 mg in the morning, during four weeks, on intragastric pH profile, occurrence of bacterial growth in gastric fluid and biopsies, and healing rate in 23 patients with an acute duodenal ulcer
Seventy patients were randomised to Fm 40 mg at night and Rn placebo and 62 to Rn 300 mg at night and Fm placebo
Recurrence rates were lower in patients receiving the higher dose of ranitidine (3
7%, p = 0
Adverse events were reported in 23 patients overall; 12 were withdrawn from the trial
After 4 wk of treatment there were no statistically significant differences in the
The trial confirmed that a single dose of ranitidine 300 mg given at night is a safe, effective alternative treatment to ranitidine 150 mg bd for the acute treatment of duodenal ulcer
The results of this trial show that 300 mg of ranitidine administered at night is an effective and safe alternative to the current twice daily regimen for the short term treatment of gastric ulcer Eight patients with previous duodenal ulcer in symptomatic remission underwent continuous intraluminal pH monitoring on five separate occasions to compare the effects on 24-h intragastric acidity of placebo, 300 mg ranitidine at night, 150 mg ranitidine twice daily, 40 mg famotidine at night, and 20 mg famotidine twice daily
Three and six days after withdrawal of dosing with ranitidine, median integrated nocturnal intragastric acidity was increased significantly (17% and The usual dosage is 150mg twice daily, taken in the morning and evening
They belong in the same medication class and both lower the amount of acid in your stomach
stomach pain, loss of appetite; dark urine, jaundice (yellowing of the skin or eyes); fever, chills, cough with mucus, chest pain, feeling short of breath; fast or slow heart rate; easy bruising or bleeding; or
05) with a significant increase of plasma gastrin concentration (+36%; p less than 0
9% v 17
Propantheline slightly delays and increases peak blood levels of ranitidine, probably by delaying Continuous measurement of 24-hour intragastric acidity was performed in 12 duodenal ulcer patients in remission during treatment with placebo, ranitidine 300 mg nocte and ranitidine 300 mg b
150 mg twice daily may be given concomitantly with NSAID therapy
and either placebo or ranitidine 300 mg at bedtime for 6 weeks in a randomized, cross-over, placebo controlled study
This concept was investigated by Khoury and colleagues in a randomized, cross-over study comparing nocturnal acid control in 20 healthy subjects receiving a 7-day course of either omeprazole 20 mg twice daily (before meals) or omeprazole 20 mg before breakfast and ranitidine 150 mg before bedtime
Antacid tablets were prescribed prn
Page 3 of 28 Tablets In respect of both 24-hour acidity and nocturnal acid output, an oral dose of ranitidine 150 mg twice daily was superior to cimetidine 200 mg three times daily and 400 mg at Twenty five patients with endoscopically diagnosed gastric ulcer, were randomly allocated to treatment with ranitidine 300 mg at night or ranitidine 150 mg twice daily
For oral dosage form (tablets): For depression: Adults—At first, 100 milligrams (mg) two times per day
Another 4 wk of therapy, in patient w/ complete healing
The 24‐hour intragastric pH of 12 patients with an acute duodenal ulcer was recorded with the aim of comparing the effects of two different times of ZANTAC 300 Tablets (ranitidine HCl equivalent to 300 mg of ranitidine) are yellow, film-coated, capsule-shaped tablets embossed with "ZANTAC 300" on one side and "Glaxo" on the other
In 2 additional US multicenter, double-blind, placebo-controlled, 2-week trials Rolf Jorde
In two additional US multicenter, double-blind, placebo-controlled, 2-week trials Foreign studies have shown that patients heal equally well with 150 mg b
(85% versus 84%, respectively) during a usual 4-week course of therapy
s
Ranitidine may be used to manage a duodenal ulcer, a type of peptic ulcer in the small intestine, as well as gastric ulcers
Endoscopy at 4 weeks showed complete
Foreign studies have shown that patients heal equally well with 150 mg twice daily and 300 mg at bed time (85% versus 84%, respectively) during a usual 4-week course of therapy
Find patient medical information for Ranitidine Hcl oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings
Adult
omeprazole twice daily plus bedtime)
The objective of this study was to compare the efficacy and safety of nizatidine 300 mg nocte 300 Mg Nizatidine at Night versus 300 Mg Ranitidine at Night in
Print Save Nizatidine Generic name: nizatidine [ ni-ZA-ti-deen ] Brand names: Axid Pulvules, Axid AR, Axid Dosage forms: oral capsule (150 mg; 300 mg), oral solution
on
It is not necessary to time the dose in relation to meals
The results of this trial show that 300 mg of ranitidine administered at night is an effective and safe alternative to the current twice daily regimen for the short term treatment of gastric ulcer Nocturnal intragastric acidity was studied before (twice), during (on day 25), and after (every 3 days for 21 days) dosing with either 300 mg ranitidine at night or 40 mg omeprazole every morning
48/57 (84%) healed on ranitidine 150 mg twice daily and 43/45 (96%) healed on 300 mg every evening (p = 0
9% v 17
05), but the antisecretory effects of nizatidine 150 or 300 mg at 21:00 h were only observed during the night, with no effect during The standard dosage regimen of Ranitidine is 300 mg at night or 150 mg twice daily to prevent heartburn and acid indigestion
The increased dose has not been associated with an increased incidence of unwanted effects
After the ulcer has healed, the dose usually goes down Nine (six men, three women) in whom healing failed to occur on this regimen after 3-15 months were treated with high dose ranitidine (300 mg bd)
Zollinger Ellison syndrome: 150 mg 3 times daily and increased if necessary up to 6 g
d
Ranitidine 300 mg hs appears to be equally safe and effective as the standard regimen of 150 mg bid in the short-term treatment of uncomplicated gastroduodenal ulcer
In a single-centre study 59 patients with gastric ulcer were treated either with 300 mg ranitidine at night or with 150 mg ranitidine twice daily
All active treatments significantly decreased 24-hr acidity, with a median suppression of 61
0% with 300 mg q
diarrhea, constipation
However, the dose is usually not more than 150 mg three times per day, taken The objective of this study was to compare the efficacy and safety of nizatidine 300 mg nocte with ranitidine 300 mg nocte in the therapy of duodenal ulceration
placebo, **P < 0
300 Mg Nizatidine at Night versus 300 Mg Ranitidine at Night in Patients with Duodenal Ulcer: A Multicentre Trial in Europe