Jul 27, 2023 · Prozac is a type of antidepressant called a selective serotonin reuptake inhibitor (SSRI)
Additionally, we describe that fluoxetine is a CYP2C9 substrate and a mechanism-based inhibitor of CYP2C19
Fluvoxamine is a potent CYP1A2 and CYP2C19 inhibitor, and a moderate CYP2C9, CYP2D6, and CYP3A4 inhibitor
Fluoxetine and its circulating metabolite norfluoxetine comprise a complex multiple-inhibitor system that causes reversible or time-dependent inhibition of the cytochrome
For example, fluoxetine also interacts with CYP2C19 and CYP3A4 but is most metabolized by CYP2D6, to which it is also a strong inhibitor (Deodhar et al
Obsessive–compulsive disorder Fluoxetine is effective in the treatment of obsessive–compulsive disorder (OCD) for adults
Selective serotonin reuptake inhibitors (SSRIs) are among the most widely prescribed class of drugs in the practice of psychiatry
Examples of CYP450 substrates include: Statins
Depressive symptoms in older adults can be the same as depression among other people
It is accepted that strong inhibitors result in nearly null enzymatic
26 An antidepressant for use in the patient receiving concomitant drug treatment, over-the-counter medications, or herbal products
In a 4-way crossover design, 16 subjects received clinically relevant doses of venlafaxine, nefazodone, or sertraline for 8 days or fluoxetine for 11 days
Find out how fluoxetine treats mental health conditions including depression, obsessive compulsive disorder (OCD) and bulimia, and how to take it
pains in the stomach, side, or abdomen, possibly radiating to the back
3A4; 2C9 moderate inhibitor fluoxetine: 2C19; 2D6 strong inhibitor 4
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For all selective serotonin re-uptake inhibitors
The usual dose of fluoxetine for children is 10mg a day but this may be increased to 20mg a day
How long to take Fluoxetine and its circulating metabolite norfluoxetine comprise a complex multiple-inhibitor system that causes reversible or time-dependent inhibition of the cytochrome P450 (CYP) family members CYP2D6, CYP3A4, and CYP2C19 in vitro
13 8 Although all of the mentioned enzymes contribute to N-demethylation of fluoxetine, CYP2D6, CYP2C9 and CYP3A4 appear to be the major contributing enzymes for phase I metabolism
Fluoxetine is an example of a CYP3A4 inhibitor in common use, and has been associated with elevated serum concentrations of antipsychotics and warfarin, but has no prior documentation of effecting metabolism of glucocorticoids
Prozac is a type of antidepressant drug called a selective serotonin reuptake inhibitor (SSRI)
DrugBank
It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs) that work by increasing the levels of serotonin in the brain